刘晓敏,中国药科大学生命科学与技术学院教授,博士生导师,江苏特聘教授。2007年本科毕业于苏州大学,2013年博士毕业于韩国庆尚国立大学,在美国康奈尔大学从事博士后研究工作,2020年加入中国药科大学。课题组重点关注RNA修饰/翻译调控肿瘤及干细胞命运的功能机制,探索开发RNA检测编辑新技术及分子药物,为疾病诊疗提供新思路及策略。相关研究成果以第一/通讯作者发表在Nat Chem Biol,Mol Cell,Cell Rep,Nucleic Acids Res,Cell Mol Life Sci等国际知名学术期刊。申请国内外专利3项,其中授权1项。作为项目负责人承担国家自然科学基金,江苏省自然科学基金,南京市留学人员科技创新项目及中国药科大学高层次人才科研启动基金等。热忱欢迎对课题组研究感兴趣的博士后,研究生及本科生加入团队。
代表性论文
(1)Wang Y#, Wang S#, Meng Z#, Liu XM*, Mao Y*. Determinant of m6A regional preference by transcriptional dynamics. (2024) Nucleic Acids Research 52(7):3510-3521
(2)Wang F#, Zhang J#, Lin X#, Yang L, Zhou Q, Mi X, Li Q, Wang S, Li D, Liu XM*, Zhou J*. METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2. (2023) Cell Reports 42(3):112150
(3)Qin M#, Huang L#, Li M#, Shao T, Zhang J, Jiang X, Shao C, Zhao C, Pan Y, Zhou Q*, Wang Y, Liu XM*, Qiu J*. Immunotoxicity Evaluation of Trihalophenolic Disinfection By-Products in Mouse and Human Mononuclear Macrophage Systems: The Role of RNA Epitranscriptomic Modification in Mammalian Immunity. (2023) Environmental Health Perspectives 131(12):127023
(4)Liu XM#*, Mao Y#, Wang S, Zhou J, Qian SB*. METTL3 modulates chromatin and transcription dynamics during cell fate transition. (2022) Cellular and Molecular Life Sciences 79(11): 559
(5)Liu XM*, Zhou J*. Multifaceted regulation of translation by the epitranscriptomic modification N6-methyladenosine. (2021) Critical Reviews in Biochemistry and Molecular Biology 56(2): 137-148
(6)Liu XM*, Wang S, Gan X, Qian SB, Zhou J*. Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution. (2021) Journal of Molecular Cell Biology 13(4): 325-328
(7)Wang S, Zhang J, Wu X, Lin X, Liu XM*, Zhou J*. Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation. (2021) RNA Biology 18(9): 1354-1363
(8)Liu XM, Zhou J, Mao Y, Ji QQ, Qian SB*. Programmable RNA N6-methyladenosine editing using CRISPR/Cas9 conjugates. (2019) Nature Chemical Biology 15(9): 865-871
(9)Liu XM and Qian SB*. Assembly en route. (2019) Nature Structural & Molecular Biology 26: 89-91
(10)Coots RA#, Liu XM#, Mao Y, Dong L, Zhou J, Wan J, Zhang X, Qian SB*. m6A facilitates eIF4F-independent mRNA translation. (2017) Molecular Cell 68(3): 504-514
联系方式
通讯地址:江苏省南京市江宁区龙眠大道639号中国药科大学江宁校区(邮编:211198)
电子邮箱:liuxm642@cpu.edu.cn
Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
E-Mail:
School/Department:分子细胞生物学系
Education Level:With Certificate of Graduation for Doctorate Study
Business Address:江苏省南京市江宁区龙眠大道639号中国药科大学江宁校区(邮编:211198)
Gender:Male
Degree:Doctoral degree
Status:在岗
Alma Mater:Gyeongsang National University
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