个人简介

沈辉，特聘研究员，博士生导师，长期致力于利用生化与分子学、细胞生物学及生物信息学等多学科方法，研究RNA结合蛋白液-液相分离性质在基因表达调控中的功能及机制。2017年11月毕业于中国科学技术大学，并获理学博士学位。2018年2月起，在美国宾夕法尼亚大学从事博士后研究工作，并于2023年加入中国药科大学生命科学与技术学院。近年来以一作/共一作在Molecular Cell、Nature Communications、Genes and Development、PNAS、ACS Catalysis、Journal of Biological Chemistry等国际知名学术期刊发表多篇论文。热忱欢迎对课题组感兴趣的本科生，研究生和博士后加入实验室，一起探索生命科学的奥秘。

联系方式

电子邮箱: shhui@cpu.edu.cn

研究方向

1. 相分离在自身免疫性疾病中调控基因表达的机制。

2. RNA修饰调控相分离的机制研究。

3. 相分离过程可逆调控的相关药物开发。

主持在研项目情况

1. 2024年江苏省青年基金项目（BK20241585）。

2. 2024年南京市留学人员科技创新项目择优资助。

近年代表性科研成果

一作（含共一）

1. Michael C Owens*, Hui Shen*, Amber Yanas, Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Xiaoyu Wei, Him Shweta, Hsin-Yao Tang, Yale E Goldman#, Kathy Fange Liu#. Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates. Nature Communications (2024).

2. Yulia Gonskikh*, Julian Stoute*, Hui Shen*, Krista Budinich, Bianca Pingul, Kollin Schultz, Heidi Elashal, Ronen Marmorstein, Junwei Shi, Kathy Fange Liu#. Noncatalytic regualtion of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia. Genes and Development (2023).

3. Hui Shen*, Amber Yanas*, Michael C Owens, Celia Zhang, Clark Fritsch, Charlotte M Fare, Katie E Copley, James Shorter, Yale E Goldman, Kathy Fange Liu#. Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Molecular cell (2022).

4. Hui Shen, Yulia Gonskikh, Julian Stoute, Kathy Fange Liu#. Human DIMT1 generates N26, 6A-dimethylation–containing small RNAs. Journal of Biological Chemistry (2021).

5. Hui Shen, Robert Jordan Ontiveros, Michael C Owens, Monica Yun Liu, Uday Ghanty, Rahul M Kohli, Kathy Fange Liu#. Journal of Biological Chemistry (2021).

6. Hui Shen, Julian Stoute, Kathy Fange Liu#. Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation. Journal of Biological Chemistry (2020).

7. R Jordan Ontiveros*, Hui Shen*, Julian Stoute, Amber Yanas, Yixiao Cui, Yuyu Zhang, Kathy Fange Liu#. Coordination of mRNA and tRNA methylations by TRMT10A. Proceedings of the National Academy of Sciences (2020).

8. Shuhuai Yu*, Hui Shen*, Yuanyuan Cheng, Yingying Zhu, Xu Li#, Wanmeng Mu#. Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue. ACS Catalysis (2018).

9. Hui Shen*, Yuwei Zhu*, Chongyuan Wang, Hui Yan, Maikun Teng, Xu Li#. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae. Scientific reports (2016).

10. Hui Shen*, Hong Wang*, Qiao Liu, Huihui Liu, Maikun Teng, Xu Li#. Structural insights into RNA recognition properties of glyceraldehyde‐3‐phosphate dehydrogenase 3 from Saccharomyces cerevisiae. IUBMB life (2014).

11. Hui Shen, Huihui Liu, Hong Wang, Maikun Teng, Xu Li#. Preliminary crystallographic analysis of RraB from Escherichia coli. Acta Crystallographica Section F: Structural Biology and Crystallization Communications (2013).

参与

1. Chun Yang, Pratik Basnet, Samah Sharmin, Hui Shen, Craig D Kaplan, Kenji Murakami#. Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3. Nucleic Acids Research (2024).

2. Alexandra E Perlegos, Xiuming Quan, Kirby M Donnelly, Hui Shen, Emily J Shields, Heidi Elashal, Kathy Fange Liu, Nancy M Bonini#. dTrmt10A impacts Hsp70 chaperone m6A levels and the stress response in the Drosophila brain. Scientific Reports (2023).

3. Alexandra M Maldonado López, Eun Kyung Ko, Sijia Huang, Gina Pacella, Nina Kuprasertkul, Carina A D’souza, Raúl A Reyes Hueros, Hui Shen, Julian Stoute, Heidi Elashal, Morgan Sinkfield, Amy Anderson, Stephen Prouty, Hua-Bing Li, John T Seykora, Kathy Fange Liu, Brian C Capell#. Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue. Science Advances (2023).

4. Megha G Basavappa, Max Ferretti, Mark Dittmar, Julian Stoute, Megan C Sullivan, Kanupriya Whig, Hui Shen, Kathy Fange Liu, David C Schultz, Daniel P Beiting, Kristen W Lynch, Jorge Henao-Mejia, Sara Cherry#. The lncRNA ALPHA specifically targets chikungunya virus to control infection. Molecular cell (2022).

5. Alexandra E Perlegos, Emily J Shields, Hui Shen, Kathy Fange Liu, Nancy M Bonini#. Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila. Nature Communications (2022).

6. Zhenhua Wang, Hui Shen, Binbin He, Maikun Teng, Qiong Guo#, Xu Li#. The structural mechanism for the nucleoside tri‐ and diphosphate hydrolysis activity of Ntdp from Staphylococcus aureus. The FEBS Journal (2021).